Welcome to the Somarowthu Lab
We are an interdisciplinary research group that integrates techniques from biochemistry, cell biology and computational biology to understand the mechanisms of important cellular pathways. Our current research is primarily focused on understanding the role of long non-coding RNAs (lncRNAs) in human biology and diseases.
1. Mazina, O.M., S. Somarowthu, L.Y. Kadyrova, A.G. Baranovskiy, T.H. Tahirov, F.A. Kadyrov, and A.V. Mazin, Replication protein A binds RNA and promotes R-loop formation. J Biol Chem, 2020.
2. Manigrasso, J., I. Chillon, V. Genna, P. Vidossich, S. Somarowthu, A.M. Pyle, M. De Vivo, and M. Marcia, Visualizing group II intron dynamics between the first and second steps of splicing. Nat Commun, 2020.
3. Shenoda, B.B., S. Ramanathan, R. Gupta, Y. Tian, R. Jean-Toussaint, G.M. Alexander, S. Addya, S. Somarowthu, A. Sacan, and S.K. Ajit, Xist attenuates acute inflammatory response by female cells. Cell Mol Life Sci, 2020.
4. Owens, M.C., S.C. Clark, A. Yankey, and S. Somarowthu, Identifying Structural Domains and Conserved Regions in the Long Non-Coding RNA lncTCF7. Int J Mol Sci, 2019.