Welcome to the Somarowthu Lab
Research Focus
​
Our laboratory investigates the molecular mechanisms by which long non-coding RNAs (lncRNAs) regulate gene expression, cellular function, and disease. We take an interdisciplinary approach that integrates cell biology, biochemistry, genomics, structural biology, and computational analysis to define how lncRNAs interact with proteins, remodel chromatin, and contribute to human disease. Our long-term goal is to identify new RNA-based biomarkers and therapeutic targets.
Recent Publications
​
1. Sarfaraz, N., et al., The Liver-Enriched Long Non-Coding RNA FAM99A Suppresses Tumorigenesis Through Negative Regulation of Protein Synthesis. J Mol Biol, 2026. 438(6): p. 169653.
​
2. Oh, M., B.L. Lee, and S. Somarowthu, Decoding the lncRNA World: Comprehensive Approaches to lncRNA Structure and Interactome Studies. Cells, 2026. 15(2).
​
3. Oh, M., et al., LncRNA SChLAP1 Promotes Cancer Cell Proliferation and Invasion Via Its Distinct Structural Domains and Conserved Regions. J Mol Biol, 2025. 437(19): p. 169350.
​
4. Yankey, A., et al., A novel partnership between lncTCF7 and SND1 regulates the expression of the TCF7 gene via recruitment of the SWI/SNF complex. Sci Rep, 2024. 14(1): p. 19384.